Pegah Shams; Hedyeh Panahi; Masoume Tahan; Fatemeh Jahansooz; Ashraf Heidaripour
Abstract
The most important challenge in the fight against cancer is the direct delivery of drugs to cancer tissues and cells. In recent years, the use of nanoparticles as drug delivery systems ...
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The most important challenge in the fight against cancer is the direct delivery of drugs to cancer tissues and cells. In recent years, the use of nanoparticles as drug delivery systems has received attention. Drug delivery systems that respond to external factors such as temperature and pH are very useful in controlling drug release from nanocarriers. The aim of this research is to investigate the effect of pH and temperature simultaneously on the release of curcumin drug (CCM) from ZIF-8 nanoparticles. X-ray diffraction and scanning electron microscopy were used to identify nanoparticles. Biocompatibility of nanoparticles was evaluated using MTT method on MCF-7 cell line as breast cancer cell. The results showed that the preparation of smart nanoparticles ZIF-8 and ZIF-8 carrying CCM (ZIF-8@CCM) and sensitive to temperature and pH was successful. The diffusion rate of CCM was optimal at acidic pH and temperature of 50 °C. Also, ZIF-8@CCM nanoparticles prevented the growth of MCF-7 cancer cells. This study is completely new and innovative and shows that ZIF-8 nanoparticles sensitive to pH and temperature and carrying CCM are suitable candidates for the treatment of breast cancer cells.
